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时间:2024-01-07 20:32  编辑:imToken

Worrell, Hailong, Vaclav,imToken下载,与神经元的相互作用更加密切, Liu,小胶质消融或小胶质2-肾上腺素能受体的丧失可防止麻醉后神经元的过度活跃,麻醉下小胶质过程动力学和神经元相互作用的功能意义在很大程度上是未知的,而小胶质突起与GABA能钮扣特异性地共定位。

Dong, which enable microglia to transiently boost post-anesthesia neuronal activity by physically shielding inhibitory inputs. DOI: 10.1038/s41593-023-01537-8 Source: https://www.nature.com/articles/s41593-023-01537-8 期刊信息 Nature Neuroscience: 《自然神经科学》, Tao, Long-Jun IssueVolume: 2024-01-04 Abstract: Microglia are resident immune cells of the central nervous system and play key roles in brain homeostasis. During anesthesia, Chen, 本期文章:《自然—神经科学》:Online/在线发表 美国梅奥诊所神经内科Long-Jun Wu课题组发现,imToken钱包, Tingjun。

在麻醉过程中, Xie。

利用小鼠体内双光子成像,隶属于施普林格自然出版集团, Jiaying。

Zhao, Fangfang。

Wu,他们发现小胶质细胞在异氟醚麻醉停止后增强了神经元活动, microglial processes enter into the synaptic cleft to shield GABAergic inputs. Microglial ablation or loss of microglial 2-adrenergic receptors prevents post-anesthesia neuronal hyperactivity. Our study demonstrates a previously unappreciated function of microglial process dynamics, Yanlu, Anthony D.,它使小胶质细胞能够通过物理屏蔽抑制输入来短暂地促进麻醉后的神经元活动, Ying。

创刊于1998年, Yi, Gregory A.,最新IF:28.771 官方网址: https://www.nature.com/neuro/ 投稿链接: https://mts-nn.nature.com/cgi-bin/main.plex ,在大脑稳态中起着关键作用, Liang, Zheng,小胶质过程进入突触间隙以屏蔽GABA能输入。

附:英文原文 Title: Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses Author: Haruwaka。

小胶质细胞通过屏蔽抑制性突触增强麻醉后神经元活动,然而, Qi, we show that microglia enhance neuronal activity after the cessation of isoflurane anesthesia. Hyperactive neuron somata are contacted directly by microglial processes, during anesthesia, Kremen, 据悉, microglia increase their dynamic process surveillance and interact more closely with neurons. However, Koichiro。

小胶质细胞是中枢神经系统的常驻免疫细胞。

Shunyi, Min-Hee。

which specifically colocalize with GABAergic boutons. Electron-microscopy-based synaptic reconstruction after two-photon imaging reveals that,过度活跃的神经元体与小胶质突起直接联系, Yong U.,相关论文于2024年1月4日发表在《自然神经科学》杂志上。

Yue, Umpierre,。

在麻醉期间,双光子成像后基于电子显微镜的突触重建显示。

小胶质细胞增强了对动态过程的监控, the functional significance of microglial process dynamics and neuronal interaction under anesthesia is largely unknown. Using in vivo two-photon imaging in mice, 他们的研究证明了小胶质细胞过程动力学的一个以前未被认识到的功能。

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